How to Reset the Tire Pressure Light (TPMS) on a GMC Sierra Denali 2500HD/3500HD

1. Set the parking brake and turn the ignition on without starting the vehicle.
2. Scroll to the Tire Pressure screen on the DIC info page.
3. Press and hold the thumbwheel, or for a base level DIC hold the trip odometer reset stem about five seconds and select yes.
4. Wait for the horn to sound twice and TIRE LEARNING ACTIVE to show on the DIC.
5. Hold the relearn tool against each tire sidewall near the valve stem and press its button, in order: driver front, passenger front, passenger rear, driver rear.
6. After the final horn sounds, turn the vehicle off and set all four tires to the pressure on the Tire and Loading Information label.

• You have two minutes for the first tire and five minutes total for all four, or the process stops and must be restarted.
• Needed after rotating tires, replacing a TPMS sensor, or swapping a spare for a road tire with a sensor.
• Uplevel DIC only: make sure the Tire Pressure info page option is turned on first.

Source: 2022 GMC Sierra Denali 2500HD/3500HD owner's manual, PDF pages 353, 354. Steps are summarized in our own words (AI-assisted, checked against the cited pages 2026-10-18). Other model years can differ; your manual has the final word.