CAR SPEC SHEET

GMC Sierra Denali 2500HD/3500HD Fuse Box: What Each Fuse Does

From the 2022 GMC Sierra Denali 2500HD/3500HD owner's manual. 3 fuse boxes listed.

FuseCircuit
1High-beam left
2High-beam right
3Headlamp left
4Headlamp right
6–
7–
8Fog lamp
9–
10–
11Police upfitter
12–
13Washer front
14Washer rear
15–
16–
17IECL 1
19DC/AC inverter
20IECR 2 (LD) / EBCM2 (HD)
21–
22IECL 2
24EBCM 1
25–
26–
27Horn
28–
29–
30–
31–
32Rear window defogger
33Heated mirror
34Parking lamp left
37–
38–
39–
40Misc ignition
41Trailer parking lamp
42Park lamp right
44–
45–
46Engine control module ignition
47Transmission control module ignition
48–
49Transmission control module
50A/C clutch
51Transfer case control module
52Front wiper
53Center high-mounted stop lamp
54Trailer reverse lamp
55Trailer back-up lamp
56SADS
57TTPM/SBZA
58Starter motor (LD & HD DSL)
60Active fuel management 1
61VES
62Integrated chassis control module/CVS
63Trailer battery
65Auxiliary underhood electrical center
66Cooling fan motor left
67Active fuel management 2
68–
69Starter Pinion (LD) / Starter Motor (HD Gas)
71Cooling fan
72Cooling fan right/lower
73Trailer stop/turn lamp left
74Trailer Interface Module 1
75DEFC
76Electric RNG BDS
78Engine control module
79Auxiliary battery
80Cabin cooling pump
81Trailer stop/turn lamp right
82Trailer Interface Module 2
83FTZM
84Trailer brake
85ENG
86Engine control module
87Injector B even
88O2 B sensor
89O2 A sensor
90Injector A odd
91Engine control module throttle control
92Cool fan clutch/ Aeroshutter
5Headlamp
18DC/AC inverter
23Rear window defogger
35Parking lamp
36Run/Crank
43–
59A/C clutch
64Starter Motor (LD & HD DSL)
70Starter Pinion (LD) / Starter Motor (HD Gas)
77Powertrain

Source: owner's manual, PDF pages 337, 338, 339.

Instrument Panel Fuse Block (Left)

Location: Driver side edge of the instrument panel

FuseCircuit
F1Rear Heated Seats Left/ Right
F3–
F4–
F5Spare/MFEG – Multifunction End Gate
F6Heated and Ventilated Seats Left/Right
F8–
F9Passive Entry Passive Start/ Spare
F10–
F11–
F12Passenger Power Seat
F13Export Power Take Off/ Special Equipment Option 1
F14–
F15–
F16AMP – Amplifier
F17–
F18–
F20Endgate
F22Rear Sliding Window
F23–
F24–
F25–
F26–
F27–
CB1–

Source: owner's manual, PDF page 340.

FuseCircuit
F1Right Doors
F2Left Doors
F3Universal Garage Door Opener
F4–
F5–
F6Front Blower
F8Lumbar Switch
F10Body Control Module 6/ Body Control Module 7
F11Seat/Column Lock Module
F12Body Control Module 3/ Body Control Module 5
F14Mirrors/Windows Module
F17Steering Wheel Controls
F18Video Processing Module/ Obstacle Detection
F19DLIS – Discrete Logic Ignition Switch
F20Ventilated Seats
F21NOT R/C
F22Heated Steering Wheel
F23MISC R/C
F24Power Take Off/Reflective Light Auxiliary Display/ Instrument Panel Cluster/ Central Gateway Module/ Inside Rear View Mirror/ Overhead Console Module Ignition
F25Heating, Ventilation, and Air Conditioning Ignition/ Heating, Ventilation, and Air Conditioning Auxiliary
F26USB Ports/Special Equipment Option Retained Accessory Power
F27Accessory Power Outlet/ Retained Accessory Power
F28Accessory Power Outlet/ Battery
F30Sensing and Diagnostic Module/Parking Brake
F31Body Control Module 4
F32Special Equipment Option/ Data Link Connection
F33Body Control Module 8
F34Cargo Lamp
F40CGM – Central Gateway Module
F41Infotainment 1
F42TCP – Telematics Connectivity Platform
F43–
F44–
F45Body Control Module 2
F46Heating, Ventilation, and Air Conditioning/Battery 1
F47Instrument Panel Cluster/ Battery
F48Transmission Control Module
F49Body Control Module 1
F50–
F51Battery 1
F52Battery 2
F53–
F54Sunroof
F55Driver Power Seat
F56DC DC TRANS 1
F57DC DC TRANS 2
F58Infotainment 2
1Accessory Power Outlet 2
2Accessory Power Outlet 1/ Cigarette Lighter
3–
4–
K1Run/Crank
K2Retained Accessory Power/ Accessory 1
K4–
K5–

Source: owner's manual, PDF pages 342, 343.

Listings are copied as text from the manual's fuse tables (AI-assisted; every circuit name was matched against the cited pages 2026-10-18). Fuse layouts can differ by trim and year; check the label on the fuse box cover before replacing a fuse, and always use the same amp rating.

Confirm with your own manual, dipstick or door-jamb label.
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